PT-141 (Bremelanotide)
A melanocortin agonist that increases sexual desire by acting on the central nervous system rather than on blood flow.
Written by Anthivera EditorialPending medical review
Updated Regulatory status verified May 1, 2026
FDA-approved
Relevance for women
FDA-approved (as Vyleesi) for hypoactive sexual desire disorder (HSDD) in premenopausal women — the strongest evidence-based peptide option in this category.
Where the evidence sits
Anthivera’s calibrated five-tier scale — what the strongest evidence on PT-141 (Bremelanotide) actually supports today.
- Preclinical
- Limited clinical
- Multiple human studies
- Phase 3
- FDA-approvedPT-141
FDA-approved: FDA-approved for the indication claimed.
Questions to bring to a consult
- 01What evidence is there for PT-141 (Bremelanotide) in women specifically — and does that include perimenopausal or postmenopausal cohorts?
- 02What is the current FDA regulatory status, and which compounding pharmacy will my prescription go through?
- 03What baseline labs do you require before starting, and how often do you monitor?
- 04What are the realistic timelines and what does “not working for you” look like in practice?
Articles on PT-141 (Bremelanotide)
How Much Does Peptide Therapy Cost?
A realistic breakdown of what peptide therapy costs — consults, the peptides themselves, bloodwork, and why insurance generally won't cover it.
PT-141 (Bremelanotide) for Women: Libido, Safety, and What to Know
PT-141 / Vyleesi is FDA-approved for low sexual desire in premenopausal women. Here's how it works, what the Phase 3 trials actually showed, and what to know about safety, off-label use, and access.
What Are Peptides? A Woman's Guide to Hormone & Wellness Peptides
A clear, evidence-based guide to peptides for women — what they are, which ones have real research behind them, and what to know before considering peptide therapy.
Providers that offer PT-141 (Bremelanotide)
- 4.6/5
Solace MD
Higher price band, faster shipping, more personal care — the right fit if cost isn't the primary constraint.
- 4.5/5
Evergreen Women's Health
Strongest fit for perimenopausal women seeking continuity of care — pairs hormone testing with peptide protocols.
- 4.0/5
Canopy Telehealth Clinic
Broad catalog and broad geographic reach; longer intake process but thorough lab work.
See the full provider comparison for all peptides side by side.